When the endocannabinoid system is exposed to too many cannabinoids. This can occur when the user is taking very high doses or increases their dosing too quickly. This can present in increased seizure activity, increased lethargy, or increased medication side-effects. When this happens, it is best to skip some doses to allow the cannabinoids to metabolize out of the body. The process of resetting the ECS is sometimes referred to as “rebooting.”