Abstract As previous work has highlighted the significance of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes with respect to cannabis dependence (CD), this study sought to characterize the neural mechanisms that…
Condition: Brain Function
Structural MRI Findings in Long-Term Cannabis Users: What Do We Know?
Please use this link to access this publication. Abstract In animal studies, tetrahydrocannabinol (THC) has been found to affect brain morphology, particularly within areas rich in cannabinoid receptors (e.g., hippocampus,…
THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia
Please use this link to access this publication. Abstract Cannabis use has been associated with an increased risk to develop schizophrenia as well as symptom exacerbation in patients. In contrast,…
The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial
Please use this link to access this publication. Abstract Rationale: Cannabis is mostly grown under illegal and unregulated circumstances, which seems to favour a product increasingly high in its main…
The effects of Δ9-tetrahydrocannabinol on the dopamine system
Please use this link to access this publication. Abstract The effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, are a pressing concern for global mental health. Patterns of…
Effects of tetrahydrocannabinol on glucose uptake in the rat brain
Please use this link to access this publication. Abstract Δ9-Tetrahydrocannabinol (THC) is the psychoactive component of the plant Cannabis sativa and acts as a partial agonist at cannabinoid type 1 and type 2 receptors in the brain….
Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV− adults
Please use this link to access this publication. Abstract Background The current study examined the independent and interactive effects of HIV and marijuana (MJ) use on brain structure and cognitive…
Does regular cannabis use affect neuroanatomy? An updated systematic review and meta-analysis of structural neuroimaging studies
Please use this link to access this publication. Abstract Regular cannabis use is associated with adverse cognitive and mental health outcomes that have been ascribed to aberrant neuroanatomy in brain…
Therapeutic Prospects of Cannabidiol for Alcohol Use Disorder and Alcohol-Related Damages on the Liver and the Brain
Abstract Background: Cannabidiol (CBD) is a natural component of cannabis that possesses a widespread and complex immunomodulatory, antioxidant, anxiolytic, and antiepileptic properties. Much experimental data suggest that CBD could be used…
FABP1 controls hepatic transport and biotransformation of Δ9-THC
Abstract The increasing use of medical marijuana highlights the importance of developing a better understanding of cannabinoid metabolism. Phytocannabinoids, including ∆9-tetrahydrocannabinol (THC), are metabolized and inactivated by cytochrome P450 enzymes…