Please use this link to access this publication. Abstract Use of cannabidiol (CBD), the most abundant non-psychoactive compound found in cannabis (Cannabis sativa), has recently increased as a result of…
Condition: Brain Function
Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease
Abstract Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with antidepressant, anxiolytic, anticonvulsant and antipsychotic effects. Thanks…
Different Effects of Cannabis Abuse on Adolescent and Adult Brain
Abstract Cannabis abuse is a common phenomenon among adolescents. The dominant psychoactive substance in Cannabis sativa is tetrahydrocannabinol (THC). However, in the past 40 years the content of the psychoactive ingredient THC…
CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons
Abstract Introduction Cannabidiol (CBD) is reported to produce pain relief, but the clinically relevant cellular and molecular mechanisms remain uncertain. The TRPV1 receptor integrates noxious stimuli and plays a key…
Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-κB-dependent signaling and glucose consumption
Please use this link to access this publication. Abstract We used mouse microglial cells in culture activated by lipopolysaccharide (LPS, 10 ng/ml) to study the anti-inflammatory potential of cannabidiol (CBD),…
Potency Assessment of CBD Oils by Their Effects on Cell Signaling Pathways
Abstract This study used nanofluidic protein posttranslational modification (PTM) profiling to measure the effects of six cannabidiol (CBD) oils and isolated CBD on the signaling pathways of a cultured SH-SY5Y…
THC Exposure is Reflected in the Microstructure of the Cerebral Cortex and Amygdala of Young Adults
Abstract The endocannabinoid system serves a critical role in homeostatic regulation through its influence on processes underlying appetite, pain, reward, and stress, and cannabis has long been used for the…
Seizure and Interictal Electroencephalographic (EEG) Changes with Cannabinoid Concentrate Use
Abstract Patient: Female, 17-year-old Final Diagnosis: Drug toxicity Symptoms: Seizure Medication: — Clinical Procedure: — Specialty: Neurology Objective: Unusual clinical course Background: The electroencephalographic (EEG) findings associated with tetrahydrocannabinol (THC)…
∆9-tetrahydrocannabinol self-administration induces cell-type specific adaptations in the nucleus accumbens core
Abstract Drugs of abuse induce cell type specific adaptations in D1- and D2-medium spiny neurons (MSNs) in the nucleus accumbens core (NAcore), that can bias signaling towards D1-MSNs and enhance…
Psychoactive Drugs Like Cannabis -Induce Hypodopaminergic Anhedonia and Neuropsychological Dysfunction in Humans: Putative Induction of Dopamine Homeostasis via Coupling of Genetic Addiction Risk Severity (GARS) testing and Precision Pro-dopamine Regulation (KB220)
Abstract Many US states now embrace the medical and recreational use of Cannabis. Changes in the laws have heightened interest and encouraged research into both cannabinoid products and the potential…