Abstract Neuronal circuits within the prefrontal cortex (PFC) mediate higher cognitive functions and emotional regulation that are disrupted in psychiatric disorders. The PFC undergoes significant maturation during adolescence, a period…
Condition: Brain Function
The Cerebellum, THC, and Cannabis Addiction: Findings from Animal and Human Studies
Please use this link to access this publication. Abstract Cannabis is the third most used psychoactive drug worldwide. Despite being legally scheduled as a drug with high harm potential and…
A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis
Abstract Emotional dysregulation and anxiety are common in people at clinical high risk for psychosis (CHR) and are associated with altered neural responses to emotional stimuli in the striatum and…
Microstructural brain abnormalities in HIV+ individuals with or without chronic marijuana use
Abstract Objective Cognitive deficits and microstructural brain abnormalities are well documented in HIV-positive individuals (HIV+). This study evaluated whether chronic marijuana (MJ) use contributes to additional cognitive deficits or brain…
Subacute cannabidiol alters genome-wide DNA methylation in adult mouse hippocampus
Please use this link to access this publication. Abstract Use of cannabidiol (CBD), the most abundant non-psychoactive compound found in cannabis (Cannabis sativa), has recently increased as a result of…
Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease
Abstract Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with antidepressant, anxiolytic, anticonvulsant and antipsychotic effects. Thanks…
Different Effects of Cannabis Abuse on Adolescent and Adult Brain
Abstract Cannabis abuse is a common phenomenon among adolescents. The dominant psychoactive substance in Cannabis sativa is tetrahydrocannabinol (THC). However, in the past 40 years the content of the psychoactive ingredient THC…
CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons
Abstract Introduction Cannabidiol (CBD) is reported to produce pain relief, but the clinically relevant cellular and molecular mechanisms remain uncertain. The TRPV1 receptor integrates noxious stimuli and plays a key…
Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-κB-dependent signaling and glucose consumption
Please use this link to access this publication. Abstract We used mouse microglial cells in culture activated by lipopolysaccharide (LPS, 10 ng/ml) to study the anti-inflammatory potential of cannabidiol (CBD),…
Potency Assessment of CBD Oils by Their Effects on Cell Signaling Pathways
Abstract This study used nanofluidic protein posttranslational modification (PTM) profiling to measure the effects of six cannabidiol (CBD) oils and isolated CBD on the signaling pathways of a cultured SH-SY5Y…