Abstract In recent years, and particularly associated with the increase of cancer patients’ life expectancy, the occurrence of cancer treatment sequelae, including cognitive impairments, has received considerable attention. Chemotherapy-induced cognitive…
Condition: Cancer
Emerging role of cannabinoids and synthetic cannabinoid receptor 1/cannabinoid receptor 2 receptor agonists in cancer treatment and chemotherapy-associated cancer management
Abstract Cannabis was extensively utilized for its medicinal properties till the 19th century. A steep decline in its medicinal usage was observed later due to its emergence as an illegal…
A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid oromucosal spray with temozolomide in patients with recurrent glioblastoma
Abstract Background Preclinical data suggest some cannabinoids may exert antitumour effects against glioblastoma (GBM). Safety and preliminary efficacy of nabiximols oromucosal cannabinoid spray plus dose-intense temozolomide (DIT) was evaluated in…
Cannabinoids in the landscape of cancer
Abstract Introduction Cannabinoids are a group of terpenophenolic compounds derived from the Cannabis sativa L. plant. There is a growing body of evidence from cell culture and animal studies in…
Cannabinoid Cancer Biology and Prevention
Abstract Plant-based, synthetic, and endogenous cannabinoids have been shown to control a diverse array of biological processes, including regulation of cell fate across cancers. Their promise as broad-based antitumor agents…
Effects of cannabidiol (CBD) on the inhibition of melanoma cells in vitro
Please use this link to access this publication. ABSTRACT Cannabidiol (CBD) is one of the most popular emerging plant extracts that is being investigated for its wide range of potential…
Cannabinoids as anticancer and neuroprotective drugs: Structural insights and pharmacological interactions—A review
Please use this link to access this publication. Abstract Cannabinoids are the major chemical constituents of the plant Cannabis sativa L. and are known to exhibit a wide range of pharmacological effects viz.,…
Therapeutic potential of cannabinoids in combination cancer therapy
Please use this link to access this publication. Abstract Derivatives of the plant Cannabis sativa have been used for centuries for both medical and recreational purposes, as well as industrial….
Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities
Abstract Cancer is a complex family of diseases affecting millions of people worldwide. Gliomas are primary brain tumors that account for ~80% of all malignant brain tumors. Glioblastoma multiforme (GBM)…
Efficacy and safety of therapeutic use of cannabis derivatives and their synthetic analogs: Overview of systematic reviews
Please use this link to access this publication. Abstract The debate on the use of cannabinoids for therapeutic purposes is constantly on the rise. This overview aimed to map the…