Please use this link to access this publication: Abstract The oxytosis/ferroptosis regulated cell death pathway recapitulates many features of mitochondrial dysfunction associated with the aging brain and has emerged as a potential…
Condition: Cellular Function
Cannabinoids Protect Cells from Oxidative Cell Death: A Receptor-Independent Mechanism
Please use this link to access this publication. Abstract Serum is required for the survival and growth of most animal cells. In serum-free medium, B lymphoblastoid cells and fibroblasts die…
Cannabidiol Modulates M-Type K+ and Hyperpolarization-Activated Cation Currents
Abstract Cannabidiol (CBD) is a naturally occurring compound found in the Cannabis plant that is known for its potential therapeutic effects. However, its impact on membrane ionic currents remains a topic of…
Effect of Cannabidiol on Human Peripheral Blood Mononuclear Cells and CD4+ T Cells
Abstract Cannabidiol (CBD), the main non-psychoactive component of Cannabis sativa L., is widely used in therapy for the treatment of different diseases and as an adjuvant drug. Our aim was to assess…
Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets
Abstract The cellular microenvironment plays a critical role in the maintenance of bone marrow-derived mesenchymal stem cells (BM-MSCs) and their subsequent cell lineage differentiation. Recent studies suggested that individuals with adipocyte-related metabolic…
Anti-inflammatory potential of CB1-mediated CAMP elevation in mast cells
Cannabinoids are broadly immunosuppressive, and anti-inflammatory properties have been reported for certain marijuana constituents and endogenously produced cannabinoids. The CB2 cannabinoid receptor is an established constituent of immune systemcells, and…
Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana
The ATP-dependent drug efflux transporter P-glycoprotein (Pgp) plays a significant role in the absorption and disposition of many compounds. The purpose of this study was to investigate the possible interaction…
Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels
Cannabinoids and the endocannabinoid system have attracted considerable interest for therapeutic applications. Nevertheless, the mechanism of action of one of the main nonpsychoactive phytocannabinoids, cannabidiol (CBD), remains elusive despite potentially…
Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
The present study investigated the inhibitory effect of cannabidiol (CBD), a major constituent of marijuana, on the catalytic activity of cytochrome P450 2C19 (CYP2C19). (S)-Mephenytoin 4′-hydroxylase activities of human liver…