Abstract Introduction: Legalization of medicinal cannabis around the world has led to an increase in the use of commercial cannabis-based products in the community. These cannabis-based products are being used…
Condition: Drug Interactions
A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers
This Phase I study aimed to assess the potential drug-drug interactions (pharmacokinetic [PK] and safety profile) of Δ9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray (Sativex®, nabiximols) in combination with cytochrome P450 (CYP450)…
Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
Evidence for an analgesic interaction between delta-9-tetrahydrocannabinol (Δ9 -THC) and morphine was sought using an experimental pain model applied to normal volunteers. The study incorporated a double blinded, four treatment,…
Interactions between cannabidiol and commonly used antiepileptic drugs
Objective: To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. Serum levels were monitored…
Combined treatment with morphine and Δ9 -tetrahydrocannibinol (THC) in rhesus monkeys: antinociceptive tolerance and withdrawal
Abstract Opioid receptor agonists are effective for treating pain; however, tolerance and dependence can develop with repeated use. Combining opioids with cannabinoids can enhance their analgesic potency, although it is…
Cannabis and its effect on anesthesia
Anesthetists are aware of the growing popularity of marijuana (cannabis). They see more of their patients admitting to its use. However, many anesthetists are not aware of the potential adverse…
Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here,…