Please use this link to access this publication. Abstract Cannabinoids reduce tremor associated with motor disorders induced by injuries and neurodegenerative disease. Here we show that this effect is mediated…
Condition: Endocannabinoid System (ECS)
The cannabinoid system and microglia in health and disease
Please use this link to access this publication. Abstract Recent years have yielded significant advances in our understanding of microglia, the immune cells of the central nervous system (CNS). Microglia are key…
Cannabis Use and the Endocannabinoid System: A Clinical Perspective
Abstract Societal attitudes toward cannabis, both as a drug of abuse and as a potential therapeutic, have undergone a marked shift in the past 25 years, resulting in wide-scale changes…
Acute effects of cannabinoid consumption on endocannabinoid levels
Please use this link to access this publication. Abstract Investigating the acute effects of cannabinoids consumption on circulating levels of endocannabinoids. Introduction Cannabis remains the most commonly used drug of abuse worldwide and…
Age-related changes in CB1 receptor expression and function and the behavioral effects of cannabinoid receptor ligands
Please use this link to access this publication Abstract Cannabinoid use has increased among aging individuals. However, little information on age-related differences in the behavioral effects of these agents is available….
Cannabinoids and the endocannabinoid system in fibromyalgia: A review of preclinical and clinical research
Abstract Characterised by chronic widespread musculoskeletal pain, generalised hyperalgesia, and psychological distress, fibromyalgia (FM) is a significant unmet clinical need. The endogenous cannabinoid system plays an important role in modulating both pain and the stress response….
The Clinical Significance of Endocannabinoids in Endometriosis Pain Management
Abstract Introduction: Patients with endometriosis often suffer from diffuse and poorly localized severe pain. The current pain management strategies include medical and hormonal therapy, as well as surgery. Medical management of…
The endocannabinoid system and orofacial pains: updates and perspectives
ABSTRACT BACKGROUND AND OBJECTIVES: Since the relatively recent discovery of the endocannabinoid system (ECS) and its fundamental role in regulating other systems, the subject has aroused interest in all areas…
Neuro-Gastro-Cannabinology: A Novel Paradigm for Regulating Mood and Digestive Health
Abstract The maintenance of homeostasis in the gastrointestinal (GI) tract is ensured by the presence of the endocannabinoid system (ECS), which regulates important physiological activities, such as motility, permeability, fluid…
Cannabis and Endometriosis: The Roles of the Gut Microbiota and the Endocannabinoid System
Abstract Endometriosis, a chronic condition affecting around 10–14% of women, is challenging to manage, due to its complex pathogenesis and limited treatment options. Research has suggested a potential role of…