Abstract The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety,…
Condition: Endocannabinoid System (ECS)
Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity
Abstract Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and could produce an “entourage effect” whereby they modulate cannabinoids to result in improved outcomes. However this…
Spinal astroglial cannabinoid receptors control pathological tremor
Please use this link to access this publication. Abstract Cannabinoids reduce tremor associated with motor disorders induced by injuries and neurodegenerative disease. Here we show that this effect is mediated…
The cannabinoid system and microglia in health and disease
Please use this link to access this publication. Abstract Recent years have yielded significant advances in our understanding of microglia, the immune cells of the central nervous system (CNS). Microglia are key…
Cannabis Use and the Endocannabinoid System: A Clinical Perspective
Abstract Societal attitudes toward cannabis, both as a drug of abuse and as a potential therapeutic, have undergone a marked shift in the past 25 years, resulting in wide-scale changes…
Acute effects of cannabinoid consumption on endocannabinoid levels
Please use this link to access this publication. Abstract Investigating the acute effects of cannabinoids consumption on circulating levels of endocannabinoids. Introduction Cannabis remains the most commonly used drug of abuse worldwide and…
Age-related changes in CB1 receptor expression and function and the behavioral effects of cannabinoid receptor ligands
Please use this link to access this publication Abstract Cannabinoid use has increased among aging individuals. However, little information on age-related differences in the behavioral effects of these agents is available….
Non-psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors-, endocannabinoids-, and NF-κB-mediated signaling
Abstract Cannabis sativa L. is increasingly emerging for its protective role in modulating neuroinflammation, a complex process orchestrated among others by microglia, the resident immune cells of the central nervous system….
Cannabinoids and the endocannabinoid system in fibromyalgia: A review of preclinical and clinical research
Abstract Characterised by chronic widespread musculoskeletal pain, generalised hyperalgesia, and psychological distress, fibromyalgia (FM) is a significant unmet clinical need. The endogenous cannabinoid system plays an important role in modulating both pain and the stress response….
The Clinical Significance of Endocannabinoids in Endometriosis Pain Management
Abstract Introduction: Patients with endometriosis often suffer from diffuse and poorly localized severe pain. The current pain management strategies include medical and hormonal therapy, as well as surgery. Medical management of…