Abstract Objective: Cannabinoids are a class of compounds that have the ability to activate two specific receptor subtypes, the cannabinoid CB1 and CB2 receptors. CB1 receptor is a G-protein-coupled receptor that…
Condition: Endocrine System
Gynecomastia and cannabis smoking: A nonassociation among US Army soldiers
An anecdotal report of gynecomastia in chronic cannabis smokers [1] stimulated research into the effect of cannabis on male hormones [2,3]. A causal association between cannabis and gynecomastia was hypothesized…
Marijuana: Interaction with the Estrogen Receptor
Crude marijuana extract competed with estradiol for binding to the estrogen receptor of rat uterine cytosol. Condensed manjuana smoke also competed with estradiol for its receptor. Pure 9-tetrahydrocannabinol, however, did…
Presence of functional cannabinoid receptors in human endocrine pancreas
Aims/hypothesis: We examined the presence of functional cannabinoid receptors 1 and 2 (CB1, CB2) in isolated human islets, phenotyped the cells producing cannabinoid receptors and analysed the actions of selective…
The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat
The effects of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on hydroxylation of estradiol and testosterone in rat liver microsomes were investigated. Acute and chronic treatment of male and female rats with…
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
During the last few years, the endocannabinoid system has emerged as a highly relevant topic in the scientific community. Many different regulatory actions have been attributed to endocannabinoids, and their…