Summary Objective To assess the benefits and harms of cannabis-based products for pediatric epilepsy. Methods We identified in this living systematic review randomized controlled trials (RCTs) and nonrandomized studies (NRSs)…
Condition: Epilepsy
Cannabinoids in treatment-resistant epilepsy: A review
Please use this link to access this publication. Abstract Treatment-resistant epilepsy (TRE) affects 30% of epilepsy patients and is associated with severe morbidity and increased mortality. Cannabis-based therapies have been…
Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence
Abstract Review evidence for cannabinoids as adjunctive treatments for treatment-resistant epilepsy. Systematic search of Medline, Embase and PsycINFO was conducted in October 2017. Outcomes were: 50%+ seizure reduction, complete seizure freedom;…
Cannabis for the Treatment of Epilepsy: an Update
Please use this link to access this publication. Abstract Purpose of Review For millennia, there has been interest in the use of cannabis for the treatment of epilepsy. However, it is only…
CBD treatment following early life seizures alters orbitofrontal-striatal signaling during adulthood
Please use this link to access this publication. Abstract Obsessive compulsive disorder (OCD) is a comorbid condition of epilepsy and often adds to the burden of epilepsy. Both OCD and epilepsy are…
An Australian nationwide survey on medicinal cannabis use for epilepsy: History of antiepileptic drug treatment predicts medicinal cannabis use
Abstract Epilepsy Action Australia conducted an Australian nationwide online survey seeking opinions on and experiences with the use of cannabis-based products for the treatment of epilepsy. The survey was promoted via…
Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex
Summary Objective Tuberous sclerosis complex (TSC) is an autosomal-dominant genetic disorder with highly variable expression. The most common neurologic manifestation of TSC is epilepsy, which affects approximately 85% of patients,…
Natural (∆9-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB1 receptor
Abstract Natural cannabinoids and their synthetic substitutes are the most widely used recreational drugs. Numerous clinical cases describe acute toxic symptoms and neurological consequences following inhalation of the mixture of…
Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis
Please use this link to access this publication. Abstract Background Approximately one-third of patients with epilepsy presents seizures despite adequate treatment. Hence, there is the need to search for new…
Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis Updated
Abstract This meta-analysis paper describes the analysis of observational clinical studies on the treatment of refractory epilepsy with cannabidiol (CBD)-based products. Beyond attempting to establish the safety and efficacy of…