Abstract Aims Despite reports that medical cannabis improves symptoms in Crohn’s disease [CD], controlled studies evaluating disease response are lacking. This study assessed the effect of cannabidiol [CBD]-rich cannabis oil…
Condition: Gastrointestinal Function
Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier
Abstract Recent studies have identified great similarities and interferences between the epithelial layers of the digestive tract, the airways and the cutaneous layer. The relationship between these structures seems to…
Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis
Abstract Background and Aims Cannabinoid receptor [CB] activation can attenuate inflammatory bowel disease [IBD] in experimental models and human cohorts. However, the roles of the microbiome, metabolome, and the respective…
A Systematic Review With Meta-Analysis of the Efficacy of Cannabis and Cannabinoids for Inflammatory Bowel Disease What Can We Learn From Randomized and Nonrandomized Studies?
Please use this link to access this publication. Abstract Goal and Background: A number of studies have investigated the effectiveness of cannabis or cannabinoids for treatment of inflammatory bowel diseases…
Cannabis sativa L. alleviates loperamide-induced constipation by modulating the composition of gut microbiota in mice
Abstract: MaZiRenWan (MZRW) is the most frequently used Traditional Chinese Medicine formula to treat chronic constipation, Cannabis sativa L. is regarded as a monarch drug in MZRW. However, the targets of Cannabis sativa L….
Cannabidiol for Functional Dyspepsia With Normal Gastric Emptying: A Randomized Controlled Trial
Please use this link to access this publication. Abstract INTRODUCTION: Cannabidiol (CBD), a CBR2 agonist with limited psychic effects, antagonizes CB1/CB2 receptors. Allelic variation CNR1 (gene for CBR1) rs806378 and FAAH rs324420 were associated…
Cannabidiol Decreases Intestinal Inflammation in the Ovariectomized Murine Model of Postmenopause
Abstract Cannabidiol (CBD) (25 mg/kg peroral) treatment was shown to improve metabolic outcomes in ovariectomized (OVX) mice deficient in 17β-estradiol (E2). Herein, CBD effects on intestinal and hepatic bile acids…
Cannabinoid 1 and mu-Opioid Receptor Agonists Synergistically Inhibit Abdominal Pain and Lack Side Effects in Mice
Abstract While effective in treating abdominal pain, opioids have significant side effects. Recent legalization of cannabis will likely promote use of cannabinoids as an adjunct or alternative to opioids, despite…
Supporting gut health with medicinal cannabis in people with advanced cancer: potential benefits and challenges
Please use this link to access this publication: https://www.nature.com/articles/s41416-023-02466-w Abstract The side effects of cancer therapy continue to cause significant health and cost burden to the patient, their friends and family,…
Neuro-Gastro-Cannabinology: A Novel Paradigm for Regulating Mood and Digestive Health
Abstract The maintenance of homeostasis in the gastrointestinal (GI) tract is ensured by the presence of the endocannabinoid system (ECS), which regulates important physiological activities, such as motility, permeability, fluid…