Background: Myeloid-derived suppressor cells (MDSCs) are getting increased attention as one of the main regulatory cells of the immune system. They are induced at sites of inflammation and can potently…
Condition: Inflammation
Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
A few years ago the endocannabinoid system has been recognized as a major neuromodulatory system whose main functions are to exert and maintain the body homeostasis. Several different endocannabinoids are…
Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid
Interleukin-6 (IL-6) is a multifunctional cytokine which contributes to inXammation and tissue injury in several diseases. Thus, inhibition of IL-6 production may be a useful strategy for treatment of patients…
The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects
Abstract Although Δ(9)-tetrahydrocannabinol (THC) and other mixed CB(1)/CB(2) receptor agonists are well established to elicit antinociceptive effects, their psychomimetic actions and potential for abuse have dampened enthusiasm for their therapeutic…
Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on…