Please use this link to access this publication. Abstract Cannabidiol (CBD) is the major non-psychotropic phytocannabinoid present in Cannabis sativa. In 2018, Congress designated certain C. sativa plant material as “hemp,” thus removing…
Condition: Inflammation
Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-κB-dependent signaling and glucose consumption
Please use this link to access this publication. Abstract We used mouse microglial cells in culture activated by lipopolysaccharide (LPS, 10 ng/ml) to study the anti-inflammatory potential of cannabidiol (CBD),…
Antinociceptive and Immune Effects of Delta-9-Tetrahydrocannabinol or Cannabidiol in Male Versus Female Rats with Persistent Inflammatory Pain
Abstract Chronic pain is the most common reason reported for using medical cannabis. The goal of this research was to determine whether the two primary phytocannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol…
Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts
Abstract Cannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis. However, CBD binds to several receptors and enzymes and, therefore, its…
Signaling through the type 2 cannabinoid receptor regulates the severity of acute and chronic graft-versus-host disease
Abstract Graft-versus-host disease (GVHD) pathophysiology is a complex interplay between cells that comprise the adaptive and innate arms of the immune system. Effective prophylactic strategies are therefore contingent upon approaches…
Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity
Abstract Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new…
Inflammation in Adolescents With Mood Symptoms Who Use THC Compared to Non-THC Users
Please use this link to access this publication. Abstract Marijuana is widely used among adolescents, particularly in those with mood and anxiety symptoms. Though inflammation is hypothesized to play a…
Cannabis against chronic musculoskeletal pain: a scoping review on users and their perceptions
Abstract Background Chronic musculoskeletal pain (CMP) may lead to reduced physical function and is the most common cause of chronic non-cancer pain. Currently, the pharmacotherapeutic options against CMP are limited…
Modulatory Potential of Cannabidiol on the Opioid-Induced Inflammatory Response
Please use this link to access this publication. Abstract Opioids are effective analgesics; however, there are many negative consequences of chronic use. One important side effect of chronic opioid use…
Potential role of cannabidiol in Parkinson’s disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation
Abstract Parkinson’s disease (PD) is a major neurodegenerative disease (ND), presenting a progressive degeneration of the nervous system characterized by a loss of dopamine in the substantia nigra pars compacta….