Condition: Insomnia


Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor

Please use this link to access this publication. Abstract Cannabis sativa has been used for improving sleep for long history. Cannabidiol (CBD) has drown much attention as a non-addictive psychoactive component…

Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study

Please use this link to access this publication. Abstract Study Objectives: Cannabidiol (CBD) is increasingly used as a health supplement, though few clinical studies have demonstrated benefits. The primary objective…

Effect of Medical Marijuana Card Ownership on Pain, Insomnia, and Affective Disorder Symptoms in Adults A Randomized Clinical Trial

Key Points Question  What are the risks and benefits of obtaining a medical marijuana card for adults who seek medical marijuana for pain, insomnia, and anxiety or depressive symptoms? Findings  In this…

UK Medical Cannabis Registry: Assessment of clinical outcomes in patients with insomnia

Abstract Introduction The primary aim of this study was to assess changes in sleep-specific health-related quality of life (HRQoL) for those prescribed cannabis-based medicinal products (CBMPs) for insomnia. Methods A…

Cannabidiol for moderate–severe insomnia: a randomized controlled pilot trial of 150 mg of nightly dosing

Please use this link to access this publication. Abstract Study Objectives: Low-dose cannabidiol (CBD) has become readily available in numerous countries; however, little consensus exists on its efficacy as a…

Longitudinal associations between insomnia, cannabis use and stress among US veterans

Summary Insomnia is highly prevalent among military veterans, with rates nearly double that of civilian populations. Insomnia typically co-occurs with other psychological problems, including substance use (e.g. cannabis) and perceived…

The impact of cannabis use on vasomotor symptoms, mood, insomnia and sexuality in perimenopausal and postmenopausal women: a systematic review

Please use this link to access this publication. Abstract Objective This study aimed to evaluate the published data on the effect of cannabis use in perimenopausal and postmenopausal women to…

Use of Cannabidiol in the Management of Insomnia: A Systematic Review

Please use this link to access this publication. Abstract Background: Cannabidiol (CBD), one of the major cannabinoids derived from the cannabis plant, is available over the counter. CBD is often used…

Evaluating possible ‘next day’ impairment in insomnia patients administered an oral medicinal cannabis product by night: a pilot randomized controlled trial

Abstract Cannabis and its major constituents, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are being widely used to treat sleep disturbances. However, THC can cause acute cognitive and psychomotor impairment and there…

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study

Abstract Insomnia or difficulty falling and or staying asleep is experienced by up to 30% of the general population. This randomised crossover double-blind placebo-controlled 6-week trial aimed to assess the…