Abstract Multiple sclerosis (MS) is known as an autoimmune disease that damages the neurons in the central nervous system. MS is characterized by its most common symptoms of spasticity, muscle…
Condition: Multiple Sclerosis
Botanically-Derived Δ9-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis
Abstract The innate immune response to bacterial and viral molecules involves the coordinated production of cytokines, chemokines, and type I interferons (IFNs), which is orchestrated by toll-like receptors (TLRs). TLRs,…
Evaluation of different phytochemicals from Cannabis sativa against Myelin oligodendrocyte glycoprotein receptor
Abstract There is a rapid spread of multiple sclerosis (MS) disorder across the globe. There are around 2.8 million cases of Multiple Sclerosis in the world; among them, 1 million are…
Therapeutic use of medical Cannabis in neurological diseases: a clinical update
Abstract The use of medical Cannabis has increased in recent years due to changing legal circumstances in many countries. Approval exists only for a few neurological conditions such as rare forms of…
Long-term assessment of the cognitive effects of nabiximols in patients with multiple sclerosis: A pilot study
Please use this link to access this publication: https://www.sciencedirect.com/science/article/abs/pii/S0303846720303334?via%3Dihub Abstract Objective: Moderate to severe spasticity is commonly reported in Multiple Sclerosis (MS) and its management is still a challenge. Cannabinoids were recently…
Safety, efficacy, and mechanisms of action of cannabinoids in neurological disorders
Please follow this link to access the full article: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30032-8/fulltext Abstract In the past two decades, there has been an increasing interest in the therapeutic potential of cannabinoids for neurological disorders…
The Broad Concept of “Spasticity-Plus Syndrome” in Multiple Sclerosis
Abstract Multiple sclerosis (MS) pathology progressively affects multiple central nervous system (CNS) areas. Due to this fact, MS produces a wide array of symptoms. Symptomatic therapy of one MS…
Cannabinoids and the expanded endocannabinoid system in neurological disorders
Abstract Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated efforts to develop cannabinoid-based therapeutics. These efforts have been…
Cannabidiol for Viral Diseases: Hype or Hope?
Abstract Background: The possibility of cannabidiol (CBD) to be used as an antiviral or to treat viral diseases has received limited attention so far, despite the growing number of claims that…