OBJECTIVE To determine the safety and pharmacokinetics of various doses of plant- derived cannabidiol (CBD) versus placebo following repeated oral administration. ANIMALS 20 healthy adult Beagles. PROCEDURES In a randomized,…
Condition: Pets
Preliminary Investigation of the Safety of Escalating Cannabinoid Doses in Healthy Dogs
Objective: To determine the safety and tolerability of escalating doses of three cannabis oil formulations, containing predominantly CBD, THC, or CBD and THC (1.5:1) vs. placebo in dogs. Design: Randomized, placebo-controlled, blinded,…
Safety and tolerability of escalating cannabinoid doses in healthy cats
Abstract Objectives: The aim of this study was to determine the safety and tolerability of escalating doses of orally delivered cannabis oils predominant in cannabidiol (CBD), tetrahydrocannabinol (THC), or both…
The Endocannabinoid System of Animals
Our understanding of the Endocannabinoid System of animals, and its ubiquitous presence in nearly all members of Animalia, has opened the door to novel approaches targeting pain management, cancer therapeutics,…
Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats
The use of cannabidiol (CBD)-rich hemp-based nutraceuticals is increasing in dogs and cats for disorders related to anxiety, seizures, cancer and pain. To date, there is little information related to…
Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs
Osteoarthritis (OA) is the most common chronic condition that dogs face. If diagnosed, it is important to focus on managing the symptoms versus find a cure. This study shows that…
US Veterinarians’ Knowledge, Experience, and Perception Regarding the Use of Cannabidiol for Canine Medical Conditions
Due to the myriad of laws concerning cannabis, there is little empirical research regarding the veterinary use of cannabidiol (CBD). This study used the Veterinary Information Network (VIN) to gauge…
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-Gl). Its structure was determined by mass spectrometry and by direct comparison with a synthetic sample. 2-Ara-Gl…