Please use this link to access this publication. Abstract Background 4−20% of people report using cannabis during pregnancy, thereby it is essential to assess the associated risks. There is some…
Condition: Pregnancy
Multigenerational consequences of early-life cannabinoid exposure in zebrafish
Please use this link to access this publication. Abstract While Δ9-tetrahydrocannabinol (THC) has been widely studied in the realm of developmental and reproductive toxicology, few studies have investigated potential toxicities from…
Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone
Please use this link to access this publication. Abstract The increased legal availability of cannabis has led to a common misconception that it is a safe natural remedy for, among…
Regional redistribution of CB1 cannabinoid receptors in human foetal brains with Down’s syndrome and their functional modifications in Ts65Dn+/+ mice
Abstract Aims The endocannabinoid system with its type 1 cannabinoid receptor (CB1R) expressed in postmitotic neuroblasts is a critical chemotropic guidance module with its actions cascading across neurogenic commitment, neuronal…
Long-term effects of maternal cannabis vapor exposure on emotional reactivity, social behavior, and behavioral flexibility in offspring
Please use this link to access this publication. Abstract The use of cannabis during pregnancy is a growing public health concern. As more countries implement legislation permitting recreational cannabis use,…
Cannabis in Pregnancy and Lactation – A Review
Abstract Cannabis (marijuana) is now legal for either medicinal use or recreational use in 33 states with more states considering legalization for medicinal and/or recreational use. More women planning pregnancy,…
One-Stop Microfluidic Assembly of Human Brain Organoids To Model Prenatal Cannabis Exposure
Please use this link to access this publication. Abstract Prenatal cannabis exposure (PCE) influences human brain development, but it is challenging to model PCE using animals and current cell culture…
Delta-9-tetrahydrocannabinol disrupts mitochondrial function and attenuates syncytialization in human placental BeWo cells
Abstract The psychoactive component in cannabis, delta-9-tetrahydrocannabinol, can restrict fetal growth and development. Delta-9-tetrahydrocannabinol has been shown to negatively impact cellular proliferation and target organelles like the mitochondria resulting in…
Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta
Abstract 1 in 5 women report cannabis use during pregnancy, with nausea cited as their primary motivation. Studies show that (-)-△9–tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient in cannabis, causes fetal growth restriction, though the…
The Cannabinoid Delta-9-tetrahydrocannabinol Disrupts Estrogen Signaling in Human Placenta
Abstract Cannabis consumption is increasing worldwide either for recreational or medical purposes. Its use during gestation is associated with negative pregnancy outcomes such as, intrauterine growth restriction, preterm birth, low…