Condition: Pregnancy


Prenatal THC Exposure Induces Sex-Dependent Neuropsychiatric Endophenotypes in Offspring and Long-Term Disruptions in Fatty-Acid Signaling Pathways Directly in the Mesolimbic Circuitry

Abstract Despite increased prevalence of maternal cannabis use, little is understood regarding potential long-term effects of prenatal cannabis exposure (PCE) on neurodevelopmental outcomes. While neurodevelopmental cannabis exposure increases the risk…

Behavioral effects on the offspring of rodent mothers exposed to Tetrahydrocannabinol (THC): A meta-analysis

Abstract Pre and perinatal administration of Tetrahydrocannabinol (THC) in rodents and their offspring has many effects that have been studied using different methods that have not been integrated using quantitative…

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner

Abstract Cannabidiol (CBD), one of the main components of cannabis, is generally considered safe. CBD crosses the placenta and its use during pregnancy is steadily increasing, the impact of gestational…

Perinatal CBD or THC Exposure Results in Lasting Resistance to Fluoxetine in the Forced Swim Test: Reversal by Fatty Acid Amide Hydrolase Inhibition

Abstract Introduction: There is widespread acceptance of cannabis for medical or recreational use across the society, including pregnant women. Concerningly, numerous studies find that the developing central nervous system (CNS) is…

Impact of cannabinoids on pregnancy, reproductive health, and offspring outcomes

Please use this link to access this publication. Abstract Cannabis is the most commonly used federally illegal drug in the United States and the world, especially among people of reproductive age. In…

Predicting Maternal and Infant Tetrahydrocannabinol Exposure in Lactating Cannabis Users: A Physiologically Based Pharmacokinetic Modeling Approach

Abstract A knowledge gap exists in infant tetrahydrocannabinol (THC) data to guide breastfeeding recommendations for mothers who use cannabis. In the present study, a paired lactation and infant physiologically based…

Prenatal Cannabinoid Exposure Elicits Memory Deficits Associated with Reduced PSA-NCAM Expression, Altered Glutamatergic Signaling, and Adaptations in Hippocampal Synaptic Plasticity

Abstract Cannabis is now one of the most commonly used illicit substances among pregnant women. This is particularly concerning since developmental exposure to cannabinoids can elicit enduring neurofunctional and cognitive…

Neonatal outcomes associated with in utero cannabis exposure: a population-based retrospective cohort study

Please use this link to access this publication: https://www.sciencedirect.com/science/article/abs/pii/S0002937823020343 Abstract Background The full spectrum of associations between in utero cannabis exposure and adverse neonatal outcomes is still unclear. Objective This study…

The effect of prenatal cannabis exposure on offspring preterm birth: a cumulative meta-analysis

Abstract Background and aims Mixed results have been reported on the association between prenatal cannabis exposure and preterm birth. This study aimed to examine the magnitude and consistency of associations…

Impact of prenatal cannabis exposure on functional connectivity of the salience network in children

Please use this link to access this publication: https://onlinelibrary.wiley.com/doi/abs/10.1002/jnr.25136 Abstract Cannabis use among pregnant people has increased over the past decade. This is of concern as prenatal cannabis exposure (PCE) is…