Abstract The endocannabinoid system (eCS), is a complex system, comprising the main endogenous ligands anandamide and 2-arachidonoyl glycerol, the cannabinoid receptors CB1 and CB2 and the biosynthetic and degrading enzymes….
Condition: Pregnancy
Marijuana Use During Pregnancy and Lactation
ABSTRACT: Cannabis sativa (marijuana) is the illicit drug most commonly used during pregnancy. The self reported prevalence of marijuana use during pregnancy ranges from 2% to 5% in most studies….
Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4
Abstract Background: Maternal cannabis use in pregnancy is linked with long-term adverse behavioral outcomes in offspring. Epigenetic processes established in utero that affect dopaminergic (reward) signaling may mediate risks. Associations between…
Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes
Marijuana is one of the most widely used substances during pregnancy in the United States. Emerging data on the ability of cannabinoids to cross the placenta and affect the development…
Maternal Marijuana Use and Adverse Neonatal Outcomes
OBJECTIVE: To estimate whether marijuana use in pregnancy increases risks for adverse neonatal outcomes and clarify if any increased risk is attributable to marijuana use itself or to confounding factors…
Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines
Objectives. Marijuana is the most commonly used illicit drug during pregnancy. Due to high lipophilicity, cannabinoids can easily penetrate physiological barriers like the human placenta and jeopardize the developing fetus….
Cannabis and Breastfeeding
Cannabis is a drug derived from hemp plant, Cannabis sativa, used both as a recreational drug or as medicine. It is a widespreadvillegal substance, generally smoked for its hallucinogenic properties….
Endocannabinoid System in First Trimester Placenta: Low FAAH and High CB1 Expression Characterize Spontaneous Miscarriage
Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were the first endocannabinoids to be characterized, that bind two G protein-coupled receptors, CB1 and CB2. AEA synthesized by multiple pathways, including NAPE-specific phospholipase D…