ABSTRACT Cannabis, the most commonly used recreational drug, is illicit in many areas of the world. With increasing decriminalization and legalization, cannabis use is increasing in the United States and…
Condition: Pulmonary Function
Acute and subacute bronchial effects of oral cannabinoids
Please use this link to access this publication. Abstract The bronchodilating activity of oral cannabinoids was evaluated in three double-blind experiments that involved the study of dose-response and interactive relationships…
Cannabis effectiveness on immunologic potency of pulmonary contagion
Please use this link to access this publication. Abstract Respiratory illnesses and its repercussions are becoming more prevalent worldwide. It is necessary to research both innovative treatment and preventative techniques….
Pulmonary effects of inhaled cannabis smoke
Please use this link to access this publication. ABSTRACT Background: The smoke generated from cannabis delivers biologically active cannabinoids and a number of combustion-derived toxins, both of which raise questions regarding…
Cannabidiol Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats
Abstract Cannabidiol (CBD) is known for its vasorelaxant (including in the human pulmonary artery), anti-proliferative and anti-inflammatory properties. The aim of our study was to examine the potential preventive effect…
Differential Effects of Cannabis and Tobacco on Lung Function in Mid–Adult Life
Abstract Rationale: Evidence suggests that the effects of smoking cannabis on lung function are different from tobacco. However, long-term follow-up data are scarce and mostly based on young adults. Objectives: To assess…
Cannabinoid receptor 2 signal promotes type 2 immunity in the lung
Abstract Type 2 immunity in the lung protects against pathogenic infection and facilitates tissue repair, but its dysregulation may lead to severe human diseases. Notably, cannabis usage for medical or recreational purposes…
Modulation of pulmonary immune function by inhaled cannabis products and consequences for lung disease
Abstract The lungs, in addition to participating in gas exchange, represent the first line of defense against inhaled pathogens and respiratory toxicants. Cells lining the airways and alveoli include epithelial…
Bronchodilator Effect of Delta-Tetrahydrocannabinol
The principal psycho-active constituent of cannabis, ∆-trans-tetrahydrocannabinol (∆-THC) has bronchodilator activity in man, both in normal subjects (Vachon, Fitzgerald, Solliday, Gould & Gaensler, 1973; Tashkin, Shapiro & Frank, 1973) and…
Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
Abstract Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that, for 2-Arachidonoylglycerol (2-AG), is mediated by monoacylglycerol lipase (MAGL). The piperidine carbamate, 4-nitrophenyl- 4-(dibenzo[d] [1,3]dioxol-5-yl (hydroxy) methyl) piperidine- 1-carboxylate…