Abstract Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules…
Condition: Sports
Cannabis Responsive Head Injury Induced Mutiple Disabilities: A Case Report
Abstract In recent years cannabinoids and their derivatives have drawn renewed attention because of their diverse pharmacologic activities. We report here one such case, where all types of medical &…
Cannabinoids and the skeleton: From marijuana to reversal of bone loss
The active component of marijuana, D9 -tetrahydrocannabinol, activates the CB1 and CB2 cannabinoid receptors, thus mimicking the action of endogenous cannabinoids. CB1 is predominantly neuronal and mediates the cannabinoid psychotropic…
Cannabinoid receptors and the regulation of bone mass
A functional endocannabinoid system is present in several mammalian organs and tissues. Recently, endocannabinoids and their receptors have been reported in the skeleton. Osteoblasts, the bone forming cells, and osteoclasts,…
Cannabinoid agonist rescues learning and memory after a traumatic brain injury
Traumatic brain injury can cause persistent challenges including problems with learning and memory. Previous studies suggest that the activation of the cannabinoid 1 receptor after a traumatic brain injury could…
Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury
Cannabidiol (CBD), a nonÂpsychoactive constituent of cannabis, has been reported to induce neuroprotective effects in several experimental models of brain injury. We aimed at investigating whether this drug could also…
Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain following hypoxiaeischemia (HI). We examined whether CBD neuroprotection is sustained over a prolonged period. Newborn Wistar rats underwent HI injury…
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
Traumatic brain injury triggers the accumulation of harmful mediators that may lead to secondary damage1,2. Protective mechanisms to attenuate damage are also set in motion2 . 2- Arachidonoyl glycerol (2-AG)…