Condition: Traumatic Brain Injury (TBI)


The effects of marijuana use prior to traumatic brain injury on survival

  Abstract Background Legalization of recreational marijuana throughout the United States has been associated with increased emergency department visits involving marijuana and its metabolites, tetrahydrocannabinol (THC) and cannabinoids. We investigated the relationship between marijuana use and outcomes…

Preinjury Use of Marijuana and Outcomes in Trauma Patients

Please use this link to access this publication. Abstract Background Recent studies have examined the effects of marijuana in various populations; however, there has been limited research on the effect…

Cannabidiol and Other Cannabinoids in Demyelinating Diseases

Effects of cannabinoid (CBD) on blood brain barrier permeability after brain injury in rats

Please use this link to access this publication. Abstract Cannabidiol is a natural herbal medicine known to protect the brain from traumatic brain injury (TBI). Here, a TBI rat model…

Recovery from Traumatic Brain Injury Following Treatment with Δ9-Tetrahydrocannabinol Is Associated with Increased Expression of Granulocyte-Colony Stimulating Factor and Other Neurotrophic Factors

Please use this link to access publication Abstract Introduction: The hematopoietic cytokine granulocyte-colony stimulating factor (G-CSF) is well known to stimulate proliferation of blood stem/progenitor cells of the leukocyte lineage, but…

Thromboembolic Outcomes in Tetrahydrocannabinol-Positive Trauma Patients With Traumatic Brain Injury

Please use this link to access publication Abstract Introduction Traumatic brain injury (TBI) is a significant source of morbidity and mortality in the United States. Recent shifts in state legislation…

Cannabidiol attenuates hypersensitivity and oxidative stress after traumatic spinal cord injury in rats

Please use this link to access publication Abstract Neuropathic pain (NP) arises as a direct consequence of traumatic spinal cord injury (SCI), which leads to devastating consequences for people suffering from this…

Cannabidiol Reduces Short- and Long-Term High Glutamate Release after Severe Traumatic Brain Injury and Improves Functional Recovery

Abstract This study aimed to determine if orally administered cannabidiol (CBD) lessens the cortical over-release of glutamate induced by a severe traumatic brain injury (TBI) and facilitates functional recovery. The…

Cannabinoids and the expanded endocannabinoid system in neurological disorders

Abstract Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated efforts to develop cannabinoid-based therapeutics. These efforts have been…

Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI

Metabolic defects and neuronal apoptosis initiated by traumatic brain injury (TBI) contribute to subsequent neurodegeneration. They are all regulated by mechanisms centered around mitochondrion. Type-1 cannabinoid receptor (CB1) is a…