Comparing Sublingual and Inhaled Cannabis Therapies for Low Back Pain: An Observational Open-Label Study
ABSTRACT
Background and Objective: Medical cannabis is becoming an acceptable treatment modality in
medicine, especially for pain relief. Concurrently, cannabis use is becoming more prevalent worldwide, a
public demand-driven trend despite the lack of established scientific basis. This observational open-label
study sought to investigate the effectiveness of cannabis therapy for alleviating low back pain symptoms.
Methods: Two types of cannabis treatment modalities were sequentially administered to chronic low back
pain patients. After an initial 1-month washout period (WO1), the first modality was cannabidiol (CBD)-rich
sublingual extract treatment administered for 10 months. Following another washout period, the second
modality, Δ⁹-tetrahydrocannabinol (THC)-rich smoked inflorescence (whole dried cannabis flowers) was
administered for 12 months.
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