Cannabis is a complex plant, with major compounds such as delta-9- tetrahydrocannabinol and cannabidiol, which have opposing effects. The discovery of its compounds has led to the further discovery of…
Keyword: ∆9-tetrahydrocannabivarin (THCV)
Plant cannabinoids: a neglected pharmacological treasure trove
Abstract Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents evidence that a plant cannabinoid, Δ9-tetrahydrocannabivarin is a…
The cannabinoid D9 -tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity
BACKGROUND: Cannabinoid type-1 (CB1) receptor inverse agonists improve type 2 diabetes and dyslipidaemia but were discontinued due to adverse psychiatric effects. D9 -Tetrahydrocannabivarin (THCV) is a neutral CB1 antagonist producing…
The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
Abstract Oxidative stress and inflammation play critical roles in the development of diabetes and its complications. Recent studies provided compelling evidence that the newly discovered lipid signaling system (ie, the…