Abstract The pharmacological importance of cannabinoids has been in study for several years. Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant, (b) endogenous as well…
Keyword: Cannabinoid receptor/s
Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats
Abstract Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are two major constituents of Cannabis sativa. Δ9-THC modulates sleep, but no clear evidence on the role of CBD is available. In order to…
Effects of cannabinoids on adrenaline release from adrenal medullary cells
Abstract The objective of the present study was to analyse the peripheral effects of cannabinoids on adrenaline release from adrenal chromaffin cells. In pithed rabbits with electrically stimulated sympathetic…
Intrahippocampal administration of anandamide increases REM sleep
A nascent literature has postulated endocannabinoids (eCBs) as strong sleep-inducing lipids, particularly rapid-eye-movement sleep (REMs), nevertheless the exact mechanisms behind this effect remain to be determined. Anandamide and 2-arachidonyl glycerol,…
Cannabinoids as therapeutic agents in cancer: current status and future implications
The pharmacological importance of cannabinoids has been in study for several years. Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant, (b) endogenous as well as (c)…
Tissue Engineering of Cartilage; Can Cannabinoids Help?
This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage…
The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent
Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors’ group. Here, the authors…
The Endocannabinoid System, Cannabinoids, and Pain
Abstract The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as…
The Emerging Role of the Endocannabinoid System in the Sleep-Wake Cycle Modulation
The endocannabinoid system comprises amides, esters and ethers of long chain polyunsaturated fatty acids. Narachidonoylethanolamide (anandamide; ANA) and 2-arachidonoylglycerol (2-AG) are endogenous cannabinoids (endocannabinoids) ligands for the cannabinoid family of…
Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
A few years ago the endocannabinoid system has been recognized as a major neuromodulatory system whose main functions are to exert and maintain the body homeostasis. Several different endocannabinoids are…