Keyword: CP55940


Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

Background and purpose: A nonpsychoactive constituent of the cannabis plant, cannabidiol has been demonstrated to haveĀ  low affinity for both cannabinoid CB1 and CB2 receptors. We have shown previously that…

Evidence that the plant cannabinoid cannabigerol is a highly potent a2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist

Background and purpose: Cannabis is the source of at least seventy phytocannabinoids. The pharmacology of most of these has been little investigated, three notable exceptions being D9 -tetrahydrocannabinol, cannabidiol and…