Keyword: CYP2C19

Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19

The present study investigated the inhibitory effect of cannabidiol (CBD), a major constituent of marijuana, on the catalytic activity of cytochrome P450 2C19 (CYP2C19). (S)-Mephenytoin 4′-hydroxylase activities of human liver…

Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes

Aims: Cannabidiol (CBD), one of the major constituents in marijuana, has been shown to be extensively metabolized by experimental animals and humans. However, human hepatic enzymes responsible for the CBD…