BACKGROUND AND PURPOSE Both CB1 and CB2 cannabinoid receptors have been shown to play a role in bone metabolism. Crucially, previous studies have focussed on the effects of cannabinoid ligands…
Keyword: Endocannabinoid/s
Cannabinoids and Cancer
Marijuana has been used in medicine for millennia, but it was not until 1964 that D9- tetrahydrocannabinol (D 9 -THC), its major psychoactive component, was isolated in pure form and…
Cannabinoids and Cystic Fibrosis: A Novel Approach to Etiology and Therapy
Cannabis stimulates appetite and food intake. This property has been exploited to benefit AIDS and cancer patients suffering from wasting disease, by administering the whole plant or its major active…
Cannabinoids and the skeleton: From marijuana to reversal of bone loss
The active component of marijuana, D9 -tetrahydrocannabinol, activates the CB1 and CB2 cannabinoid receptors, thus mimicking the action of endogenous cannabinoids. CB1 is predominantly neuronal and mediates the cannabinoid psychotropic…
Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
Abstract Background and purpose: Activation of cannabinoid receptors decreases emesis, inflammation, gastric acid secretion and intestinal motility. The ability to modulate intestinal permeability in inflammation may be important in therapy aimed…
Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation
Abstract This review covers reports published in the last 5 years on the anti-inflammatory activities of all classes of cannabinoids, including phytocannabinoids such as tetrahydrocannabinol and cannabidiol, synthetic analogs such as…
Cannabinoids, Immune System and Cytokine Network
How cannabinoids influence immune function has been examined extensively in the last 30 years. Studies on drug-abusing humans and animals, as well as in vitro models employing immune cell cultures,…
Cannabinoids, inflammation, and fibrosis
Abstract Cannabinoids apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs). As a class, the cannabinoids are generally free from the adverse…
Cannabis and Amyotrophic Lateral Sclerosis: Hypothetical and Practical Applications, and a Call for Clinical Trials
Significant advances have increased our understanding of the molecular mechanisms of amyotrophic lateral sclerosis (ALS), yet this has not translated into any greatly effective therapies. It appears that a number…