Cannabinoids, the active components of Cannabis sativa (marijuana) and their endogenous counterparts, exert their effects by binding to specific G-protein-coupled receptors that modulate adenylyl cyclase and ion channels. Recent research…
Keyword: Extracellular signal–regulated kinase (ERK)
Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
Normal tissue toxicity limits the efficacy of current treatment modalities for glioblastoma multiforme (GBM). We evaluated the influence of cannabinoids on cell proliferation, death, and morphology of human GBM cell…