Abstract Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are two major constituents of Cannabis sativa. Δ9-THC modulates sleep, but no clear evidence on the role of CBD is available. In order to…
Keyword: insomnia
Insomnia treatment: a new multitasking natural compound based on melatonin and cannabis extracts
Abstract Objectives. Our main aim was to investigate the short-term therapeutic effects, safety/tolerability of natural compound, composed of melatonin (1,5 mg) and cannabis extracts (2.5 mg CBD) in patients with…
Medical cannabis and insomnia in older adults with chronic pain: a cross-sectional study
Having chronic pain can make it difficult to sleep through the night. And having a lack of sleep can compound the effects of any health issue, leading to a vicious…
(−)δ9 THC as an hypnotic
(−)δ 9 THC was found to significantly decrease the time it takes to fall asleep in physically healthy insomniacs. Once asleep, interruptions of sleep were not significantly altered over the…
The effects of cannabinoid administration on sleep: a systematic review of human studies
This paper reviews the literature regarding the effects of cannabinoid administration on sleep in humans. A literature search using a set of cannabinoid and sleep-related terms was conducted across eight…
The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent
Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors’ group. Here, the authors…