Abstract Background and Purpose HU-211 is a nonpsychotropic cannabinoid analogue that has been shown to act as a functional N-methyl-d-aspartate receptor blocker. We investigated the neuroprotective efficacy of HU-211 in a model…
Keyword: rat/s
Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers
The primary aim of the present study was to determine the expression levels of cannabinoid receptor type 1 (CB1) in steatotic rat livers. The secondary aim was to clarify whether…
Marijuana, Tetrahydrocannabinol, and Pulmonary Antibacterial Defenses
Although marijuana is now consumed extensively, little is known of its biologic effects on the lung. To study this problem, the intrapulmonary inactivation of an aerosolized challenge of Staphylococcus aureus…
Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver
Effects of four cannabinoids [cannabidiol (CBD), delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol, and cannabinol] on hepatic microsomal oxidation of testosterone (17 beta-hydroxy-androst-4-ene-3-one) were examined in adult male rats. Only CBD (30 microM)…
Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic component of the Cannabis sativa…