Keyword: safety


A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose, Multiple Dose, and Food Efect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purifed Cannabidiol in Healthy Subjects

Abstract Background: A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD, the maximum tolerated dose,…

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies

Introduction: This literature survey aims to extend the comprehensive survey performed by Bergamaschi et al. in 2011 on cannabidiol (CBD) safety and side effects. Apart from updating the literature, this…

Review on clinical studies with cannabis and cannabinoids 2010-2014

In 2010 a review by Hazekamp and Grotenhermen covered controlled clinical trials of the years 2006-2009 on cannabis-based medicines, which followed the example of the review by Ben Amar (2006)….

Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent

Cannabidiol (CBD), a major nonpsychotropic constituent of Cannabis, has multiple pharmacological actions, including anxiolytic, antipsychotic, antiemetic and anti-inflammatory properties. However, little is known about its safety and side effect profile…